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Implants for nervous system
Kuruc, Lukáš ; Zatloukal, Miroslav (referee) ; Sedlaříková, Marie (advisor)
This thesis deals with implants for nervous system. The first part of this thesis focuses on theoretical analysis of this issue, makes reader familiar with seriousness of spinal cord injury, its treatments options and regeneration with hydrogel implants. The second part describes experimental manufacturing of implants, testing patency and summary of their properties.
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Live-in personal assistance for people with quadriplegia
Pařízková, Kateřina ; Pavlová, Ilona (advisor) ; Čichoň, Rostislav (referee)
Author: Bc. Kateřina Pařízková Title: Live-in Personal Assistance for Individuals with Quadriplegia Objectives: The aim of the thesis is to find out if the live-in assistance described below would be in demand by quadriplegics in the Czech Republic and if there would be social service workers who would be interested to do the work following the British model. The outcome of this work could help to improve the quality of care for people with quadriplegia and quality of their life. Methods: In the research section, a quantitative research analysis is conducted using two surveys of their own design, one for individuals with quadriplegia and another for social service workers. This information will help ascertain whether individuals with quadriplegia in the Czech Republic currently avail themselves of personal assistant services and whether they would be receptive to adopting the widely utilized British Live-in system. The results are supplemented with data from social workers in the Czech Republic who provided information about their interest in performing Live-in assistance through a questionnaire survey. Results: The first survey involved 284 respondents aged 18-65 years. Within this survey, it was found that social service workers liked the mentioned position of Live-in assistant. They positively...
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Axon, in development and injury
Polčanová, Zuzana ; Kárová, Kristýna (advisor) ; Novák, Ondřej (referee)
The cytoskeletal structure of growth cones plays an important role in both the development of the nervous system and during periods of axon re- generation. The growth cone is a highly dynamic structure located at the tip of growing axons, providing navigation and movement. Signalling cascades are activated that lead to the regulation of the growth cone cytoskeleton, defining its displacement, rotation, or collapse. Despite advances in under- standing guidance cues and their mechanisms of action, knowledge of what happens to the nervous system after injury is lacking. Unlike axons in the peripheral nervous system (PNS), that are able to regenerate after neuronal injury, axons in the central nervous system (CNS) loose regenerative ability as they mature. Unravelling the mechanisms of axon guidance, together with their behaviour after axotomy and regeneration, is extremely important for the understanding of CNS injuries and to provide treatment of these injuries in the future.
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The interference of muscular imbalance on people with spinal cord injury using method of Spiral stabilization
Turanská, Alexandra ; Vařeková, Jitka (advisor) ; Kovařovic, Vojtěch (referee)
Title: Influencing muscle imbalances in persons with transverse spinal cord injury using the spiral stabilization method Objectives: The main aim of this thesis was to investigate whether muscle imbalances in people with spinal cord lesions can be influenced by practicing the spiral stabilization method. Methods: Six wheelchair floorball players (5 male and 1 female), aged 36-52 years, with spinal cord lesions at the Th4-11 level (5 complete, 1 incomplete), 5 of whom had no previous experience with the spiral stabilization method, participated in the study. During the 3-month intervention, it was investigated whether the spiral stabilization method could be used to influence muscle imbalances in subjects with ML. Kinesiological assessment of muscle imbalances by faceting and palpation, sitting assessment using the Xsensor pressure mapping system, training diary and subjective assessment of the intervention by probands were used as data collection methods. All probands were provided with a video guide to follow during the study. Interest in practicing this method after the research was also surveyed. Results: Based on the results of the research, it can be said that the training of the spiral stabilization method had a positive effect on the influence of muscle imbalances and improvement of sitting...
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Energy needs and body composition in individuals with transverse spinal cord injury
Pavlíčková, Jana ; Sadílková, Aneta (advisor) ; Staňová, Alžběta (referee)
Introduction Spinal cord injury is associated with negative changes in body composition, glucose and lipid metabolism. This fact is responsible for a higher risk of metabolic complications in patients with a transverse spinal cord lesion (TML). Individuals tend to achieve a positive energy balance, which leads to an increase in adipose tissue, the development of overweight and obesity and other diseases, and last but not least, to the deterioration of self-sufficiency. Setting optimal energy intake is main key to maintain the patient's health and quality of life. Target The aim of this bachelor's thesis is to determine resting energy rate (RMR) in people after a transverse spinal cord injury. The subject of interest is also the comparison of the results with the prediction equation of Harris-Benedict with the indirect calorimetry (NK) method, to determine the body composition and determine the real energy intake of the diet. A control set of healthy individuals without the handicap of a transverse spinal cord lesion was chosen for the comparison of the obtained data. Methodology The research group consists of adults after a transverse spinal cord lesion. There were 26 people included, 11 women and 15 men, clients of the non-profit organization Centrum Paraple, o.p.s. The average age is 40.3 years...
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Functional independence measures in wheelchair rugby players
Moudrá, Kristýna ; Vařeková, Jitka (advisor) ; Pavlová, Ilona (referee)
Title: Functional independence measures in wheelchair rugby players Objectives: The aim of the thesis is to investigate the relationship between the sports activity of wheelchair rugby players and the degree of functional independence in daily activities in people with spinal cord injury. Methods: 20 male wheelchair rugby players aged between 20 and 51 years, in the range of spinal cord injury level C5 - Th8, were selected for the empirical mixed research using the purposive sampling method. The methods of data collection include an interview and a self-constructed questionnaire that elicits anamnestic data, subjective assessment of self- sufficiency and player's experiences with health complications associated with wheelchair rugby. Furthermore, an evaluation of the SCIM III functional degree of independence was carried out, the results of which were compared with the results of two previous studies (EMSCI and assumptions of Occupational Therapists from the Czech Republic). Results: The results confirm a positive relationship between the player's functional independence and the sports activity of wheelchair rugby players. Respondents at levels of complete spinal cord injury C6 and C7-8 with the SCIM III assessment demonstrated a higher functional independence rate compared to the overall average...
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The role of the nurse in providing multidisciplinary care in spinal units
HARAZINOVÁ, Lucie
The aim of this master's thesis is to map the role of the nurse in the spinal unit, describe the collaboration of multidisciplinary team members in the spinal unit and describe the needs of the hospitalized patients. To meet these objectives, a total of five following research questions were set: "What is the role of the nurse in the care of patients in the spinal unit?", "What are the specifics of nursing care of patients in the spinal unit?", "What is the composition of the multidisciplinary team in the spinal unit?", "How does the cooperation between these workers take place?" and "What are the needs of patients hospitalized in the spinal unit?". The theoretical part of the thesis is designed to provide the reader with a comprehensive overview of the issue of spinal cord injury. At the very beginning, it defines the basic anatomical and physiological conditions of the nervous system, spine and spinal cord. Injury of these structures is the subject of other chapters, which discuss the causes, symptoms, diagnosis and treatment options in more detail. It also describes the development of spinal units in the Czech Republic and abroad. It defines a multidisciplinary team, whose work is an integral part of the care of a patient with a spinal cord injury. The nursing care chapter is devoted to areas that require a specific approach by nurses in patients with spinal cord injury. A qualitative research study was chosen for the empirical part of the thesis. Data collection took place using a semi-structured interview with thirteen nurses from selected spinal units. After finding out their personal information, they were asked a total of twenty-nine questions focused on the functioning of the spinal unit, characteristics of provided multidisciplinary care and the nurses' experience of the patients' condition and needs. The obtained information was subsequently transcribed and processed with the open coding method and colouring text. For easier orientation in the results of the interviews, four categories and seventeen subcategories were created, which clearly present the answers to the above research questions. It was found that the informants perceive their role in the spinal unit mainly as a nurse-caregiver. The cooperation of the multidisciplinary team is conditioned by various forms of verbal and non-verbal information exchange, for example during ward rounds, by change-of-shift handoff, operational meetings or information boards. Most of the nurses rate this cooperation as effective and mostly problem-free. The results also show that the needs of patients are closely related to mobility restrictions and long-term hospitalization. Most often, these are physiological needs and the need for contact with the society. This master's thesis points out the importance of a multidisciplinary and sensitive approach to patients with a spinal cord injury, who experience many worries and tense moments in their return to everyday life. The results may serve as educational material not just for students of healthcare professions, but also for the medical staff themselves. An output of the thesis is a manual for new nurses on spinal units, which aims to make them easier to integrate and prepare for the significant specifics about the nursing care for patients with spinal cord injury.
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Study of mechanisms influencing inflammatory and neurodegenerative processes and their subsequent treatment in ALS and spinal cord injury
Vargová, Ingrid ; Jendelová, Pavla (advisor) ; Jiruška, Přemysl (referee) ; Balaštík, Martin (referee)
Study of mechanisms influencing inflammatory and neurodegenerative processes and their subsequent treatment in models of ALS and spinal cord injury The mechanisms of neurodegeneration during spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) are complex and poorly understood, which is why it's troublesome to counteract them with effective therapies. This thesis explores the pathways of autophagy, endoplasmic reticulum (ER) stress, and the mammalian target of rapamycin (mTOR) pathway that regulates these mechanisms in models of both SCI and ALS. Upregulation of autophagy and the mTOR pathway in an in vivo contusion SCI injury model was confirmed. The mTOR inhibition led to upregulation of autophagy, reduction of inflammation, and recovery in acute SCI. Upregulated autophagy was discovered in the SOD1G93A rat model of ALS. By treating the ALS rats with human mesenchymal stem cells, prolonged survival of the animals and preservation of motor neurons (MNs) possibly occurred through modulation of autophagy. The involvement of the mTOR pathway in the degeneration of MNs was further explored in the context of astrocytes. Pleckstrin homology like domain family A member 3 (PHLDA3), a newly discovered repressor of the mTOR pathway, was found to lead to ER stress if overexpressed in astrocytes...
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Assessment methods used in prescribing and verifying the effect of physical activity in people after spinal cord injury
Šlauf, Milan ; Vařeková, Jitka (advisor) ; Křivánková, Markéta (referee)
Title: Assessment methods used in prescribing and verifying the effect of physical activity in people after spinal cord injury Objectives: The main aim of this work was to examine the prescription of physical activities in aftercare in individuals with spinal cord lesions by experts in spinal rehabilitation. The extent, forms and methods of prescribing physical activities and verifying the effect of this education were examined. Methods: Quantitative type of research using the research technique of the own design questionnaire. The questionnaire was focused on recommendations in rehabilitation and physical activity and subsequent control of physical activity. The research group consisted of 28 respondents (14 men and 14 women) - experts on spinal issues involved in the follow-up care of individuals with spinal cord injuries in various positions (11 physiotherapists, 9 occupational therapists, 5 movement therapists, 2 self-sufficiency instructors and 1 doctor). Results: Physical activity has an irreplaceable role in the follow-up care of patients with spinal cord lesions. All respondents (28) educate about the importance of physical activity. A large proportion of respondents (71 %) retrospectively check the performance of physical activities using various types of investigation forms. Respondents...
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Pathological consequences of hypokinesis in paraplegic patient and their identification by TVS method
Vavrová, Dominika ; Jelen, Karel (advisor) ; Čichoň, Rostislav (referee)
Thesis title: Pathological consequences of hypokinesis in paraplegic patient and their identification by TVS method The thesis focus: The focus of the thesis was to identify and classify differences of mechanical properties of axial systems between paraplegic patient and people from healthy population. Secondary focus of the thesis was to identify and classify changes of mechanical properties of axial system in paraplegic patient depending on physiotherapeutic intervention. The research methods: Three people, one paraplegic person and two healthy people were measured with TVS (Transfer Vibration Through Spine) method. Paraplegic person was measured twice, before and after one hour long physiotherapeutic intervention (PI). Healthy people were measured once, without PI. TVS method is a diagnostic apparatus that enables qualitative and quantitative classification of properties of axial skeleton and its segments. It is based on fact that velocity of mechanical waves and density of mechanical energy transmitting through axial skeleton is affected by properties of this system. Thus we were able to analyze and identify mechanical properties of measured axial systems according to differences of input and output values of acceleration on particular spinous processes. The results: When we compared frequency...
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